An Evidence-based Comparison of Biological Dressing Versus Conventional Treatment in Burns : An Economic Evaluation

Abstract

Abstract Introduction: Burn is a global problem and the most common cause of trauma in developing countries and, the treatment of these types of wounds have been allocated a large part of the resources. Therefore, the aim of this study was to assess the clinical effectiveness and cost-effectiveness of biological dressing and traditional dressing (SSD) in treatment of burn injuries, to help health policy makers and health financial providers. Method and Material: At first, a systematic review was done to assess the effectiveness of two types of dressing. We were searched on pubmed, Ovid, Scopus, and ProQuest databases, using keywords such as Biological dressing, Xenograft, Xenoderm, Amniotic membrane, Pig skin, Porsin skin, and Allograft, until March 2115. Cost data was collected from 231 patient records, including direct of medical and semi-medical variables costs. Then, using the TreeAge11 software, a decision tree was drawn and the cost-effectiveness was assessed with the perspective of the health system. Results:A total of 1،688 article, finally 8 articles were entered into the meta-analysis. The results from the comparison of biological dressing and SSD, mainly indicate a decrease in mortality and albumin injection in the biological dressing group. The costs and preventive DALI were estimated in the biological group were respectively 216453532Rials and 1.62 per patient, and in the traditional group it was 132486138Rials and1.145 per patient. Conclusion: according to our study results Biologic dressing can improve clinical and economic outcomes. Further analysis frome wider perspectives on costs and outcomes would provide better evidence for decisionmaking. Keywords: Biological dressing, SSD, Cost-effectiveness, DALY