Solubility correlation of structurally related drugs in binary solvent mixtures

Abstract

Applicability of the well-established cosolvency equation, i.e. combined nearly ideal binary solvent/Redlich-Kister, CNIBS/R-K, model for calculating the solubility of structurally related drugs in a given cosolvent and water mixtures is presented. The accuracy and predictability of the model are also compared with those of two other models. Computational results show that the CNIBS/R-K model provides very reasonable solubility predictions for the solutes considered, and the CNIBS/R-K model is superior to the other two models. (C) 1998 Elsevier Science B.V. All rights reserved.