سنتزوبررسی رهش دارو از هیدروژلهای هوشمند مغناطیسی حاوی داروی ضد سرطان دوکسوروبیسین هیدروکلراید

Abstract

Thermosensetive poly(N-isoprpyl acrilamid)-based magnetic nanoparticles were synthesize by free radical polymerization of N-isopropylacrilamid (NIPPAMs) , methacrylic acid (MAA) , and vinyl pyrolidon (VP) in the persece of triethylenglycoldimethacrylate as crosslinking agent.The Fe3O4magnetic nanoparticls were prepared by chemical percipitation of Fe3O4 salts in the ratio of 12 under alkalin and inert condition.Thermosensitive crosslinked P(NIPAAM-maa-VP) copolymer were characterized by FT-IR and H-NMR .The pH and thermosensitive copolymer was used for perparation of drug_loaded magnetic nanoparticles,doxorubicin(DOX) was used as a typical anticancer drug. The amount of the loaded drug and drug release amount were determined by UV measurements.scaning electron microscopy(SEM) and differential scaning calorimetry(DSC)were used to detrmine the particle surface morphology and glass tranition temperature)Tg) respectively.DSC showed that there was a relatoin between the polymr structure and theral properties.SEM micrographs indicated that the particls were cpherical with particle sizes in the range of 100nm.The release behavior of DOX at pH= 7.4 and 37C WAS STUDIED.The resaltindicated that this thermosensetive magneic nanoparticles has a high drug loading capacity and favorable linear release property for DOX without initial burst release.Thus this system is promising for the application in tareted smart anticancer drug delivery.Thermosensetive poly(N-isoprpyl acrilamid)-based magnetic nanoparticles were synthesize by free radical polymerization of N-isopropylacrilamid (NIPPAMs) , methacrylic acid (MAA) , and vinyl pyrolidon (VP) in the persece of triethylenglycoldimethacrylate as crosslinking agent.The Fe3O4magnetic nanoparticls were prepared by chemical percipitation of Fe3O4 salts in the ratio of 12 under alkalin and inert condition.Thermosensitive crosslinked P(NIPAAM-maa-VP) copolymer were characterized by FT-IR and H-NMR .The pH and thermosensitive copolymer was used for perparation of drug_loaded magnetic nanoparticles,doxorubicin(DOX) was used as a typical anticancer drug. The amount of the loaded drug and drug release amount were determined by UV measurements.scaning electron microscopy(SEM) and differential scaning calorimetry(DSC)were used to detrmine the particle surface morphology and glass tranition temperature)Tg) respectively.DSC showed that there was a relatoin between the polymr structure and theral properties.SEM micrographs indicated that the particls were cpherical with particle sizes in the range of 100nm.The release behavior of DOX at pH= 7.4 and 37C WAS STUDIED.The resaltindicated that this thermosensetive magneic nanoparticles has a high drug loading capacity and favorable linear release property for DOX without initial burst release.Thus this system is promising for the application in tareted smart anticancer drug delivery.