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Assessment of effect of jadwar capsule (Delphinium Denudatum) on clinical manifestation of knee Osteoartheritis versus pelacebo : A double blind randomized controlled clinical trial
(Tabriz University of Medical Sciences, School of traditional medicine, 2022) baghervand navid, roghayeh; ghojazadeh, morteza; tradtinal medicine; karimi, mehrdad; fazljou, seyed mohammad bagher
Abstract Introduction: Osteoarthritis is the most common arthritis which is characterized by degeneration of articular cartilage. The most important symptoms are joint pain, stiffness, movement, deformity, different effect from the subject. Osteoarthritis is rated as the fifth cause of the year of life last index in high income countries and ninth in low to middle income countries. Due to complications of medical and surgical interventions and the growing demand to herbal medicine, the research on the medicinal plants can be decide as a beneficial strategy. One of the most useful plants in the Traditional Persian Medicine is Jadwar (Delphinium denudatum wall.).Jadwar is used as medicinal plant in many diseases in Traditional Persian Medicine. One of the most important usages of Jadwar in Traditional Persian Medicine is for joint problems like, arthralgia, joint stiffness, and arthritis. Aim: Determining the effect of Jadwar (Delphinium denudatum wall.) on clinical manifestation of knee Osteoarthritis versus placebo Methods: 104 patients with mild to moderate knee osteoarthritis met the inclusion criteria and after obtaining informed consent, detailed history and clinical examination were performed. Patients allocated to the two equivalent groups of 52 people (intervention and control groups) randomly using the block design method. Jedwar and placebo capsules were identical in appearance and were placed in the same shaped containers, and in order to the allocation concealment, by someone other than the researchers, the drug containers were placed in identically numbered seeled envelopes. In the next step the intended drug (jadwar and placebo capsules) prescribed to patients. Patient consumed the drugs two times a day for four week. The outcomes, including pain, stiffness, and physical activity were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire and the Visual Analogue Scale (VAS) at baseline two and four weeks after the intervention. Results: The statistical comparison between intervention and control groups showed that the jadwar significantly reduces the pain compared with control group according to the vas questionnaire (P=0.0000). Also according to the womac questionnaire the statistical analysis showed that the jadwar reduces the pain and stiffness of knee and improves the physical activity of patients better than placebo. This effect was statistically significant at the end of the second week for VAS index and improvement of physical activity by WOMAC index and for all indices in the fourth week (end of study) (P = 0.000). Conclusion: This study showed that taking oral capsules twice a day orally on the symptoms of patients with mild to moderate osteoarthritis for one month has a better effect on reducing pain, dryness and improving patients' daily activities than placebo capsules.
Celery plus Anise Versus Metformin for the Treatment of Oligomenorrhea in the Polycystic Ovary Syndrome: A Triple-blind Randomized Clinical Trial
(Tabriz University of Medical Sciences, School of Traditional Medicine, 2018) Moini Jazani, Arezoo; Tansaz, Mojgan; Nazemyieh, Hossein; Sadeghi Bazargani, Homayoun; Traditional medicine; Hamdi, Kobra; Fazljoo, Seyed Mohammad Bagher
Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) with metformin (met.) on oligomenorrhea in PCOS patients. Methods: We conducted a triple-blind clinical trial, and 72 patients were randomly allocated into two equal groups and received six capsules of either CAC (750 mg each) or met. (250 mg each) in 3 divided doses for 15 days beginning with the follicular phase. If the bleeding occurred, three capsules of either placebo or met. would be administered daily during menstruation phase, and then the follicular phase step with six capsules would be repeated. If the bleeding did not occur, three capsules of either placebo or met. would be administered each day for 15 days. The regularity of menstrual bleeding as the primary outcome, as well as testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications were assessed before and after three cycles. Results: The mean age ± standard deviation of all patients was 26.5±6.1. Also, mean Body Mass Index was 26.4±3.5. CAC significantly improved oligomenorrhea (58.3% vs 25%, p<0.01), increased bleeding episodes (p=0.003) and reduced testosterone (mean difference 0.16 vs -0.02, p=0.005) and LH/FSH (mean difference 0.75 vs -0.08, p=0.002) without any major side effects compared to the met. group. Conclusions: we showed that CAC can regulate menstrual cycles and improve oligomenorrhea in PCOS patients superiorly to met.
The effect of Iranian Traditional Medicine treatment based on Withania somnifera on sperm parameters in the infertile men: A Randomized, Triple-Blind, controlled clinical trial
(Tabriz University of Medical Sciences, School of Traditional Medicine, 2018) Nasimi Doost Azgomi, Ramin; Nazemyieh, Hossein; Sadeghi Bazargani, Homayoun; Nejatbakhsh, Fatemeh; Traditional medicine; Zomorrodi, Afshar; Fazljou, Seyed Mohammad Bagher
Withania somnifera (WS) is a medicinal herb that is used in Persian medicine to treat male infertility. Thus, we aimed to assess and compare the effects of WS and pentoxifylline on the sperm parameters in idiopathic male infertility. This study was a triple-blind randomized clinical trial. 100 infertile male patients were randomly allocated into either WS or pentoxifylline groups. Patients in the herbal group received 6 capsules containing 5 g/daily of WS root and in the pentoxifylline group subjects received 6 capsules containing 800 mg/daily of pentoxifylline and placebo for 90 days. Sperm parameters were analyzed at the beginning and end of the study. Results showed that WS administartion significantly increases mean sperm count (12.5%) as well as progressive motility (21.42%) and improved sperm morphology (25.56%) compared to the baseline (p=0.04, p=0.001 and p=0.000, respectively). We also showed that pentoxifylline treatment remarkably increased mean semen volume (16.46%) as well as progressive motility (25.97%) and improved sperm morphology (13.28%) compared to the baseline (p=0.02, p=0.003 and p=0.01, respectively). Intergroup comparison showed no statistically significant differences between two groups on the sperm parameters after 90 days. No major complication was reported either in WS or PTX groups. WS and pentoxifylline both improve sperms parameters in idiopathic male infertility. However, the impacts of two treatments were not different. Due to no noticeable adverse effects, this medication can be an alternative choice in the treatment of idiopathic male infertility.

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