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A 15-year study of hydatid cyst in children admitted to Tabriz Pediatric Medical Center
(Tabriz University of Medical Sciences, Faculty of Medicine, 2020) Khodabandelou, Maryam; Abdoli-Oskouei, Shahram; Aslanabadi, Saeed
The aim of this study was to evaluate the cases of hydatid cysts in children admitted to Tabriz Pediatric Medical Center for 15 years. Materials and Methods: In this cross-sectional study, all children diagnosed with hydatid cyst who were referred to pediatric clinics in Tabriz during the last 15 years from 2003 to 2016 were studied. 120 patients were included in the study. Hydatid cysts in the lung were divided into right lung cysts, left lung cysts and bilateral cysts. In this study, the characteristics of hepatic hydatid cysts were examined and divided into left lobe cysts, right lobe cysts and bilateral cysts. Results: The mean age of the patients was 8.79±3.75 years and 59.2% of them were male. 52 patients (43.3%) lived in cities and 68 patients (56.7%) lived in villages. 77 patients (64.2%) had a positive relationship with livestock. The mean size of liver cyst in the studied patients was 55.45±24.19 mm with a range between 20 to 120 mm and the average size of lung cyst in the studied patients was 45.47±24.57 mm with a range between 15 to 130 mm.
5 year study of CBC changes after scoliosis surgery
(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Yousefzare, Siavash; Hosein Pouefeizi, Hojjat; Parish, Masoud
Scoliosis is one of the most common spinal deformities and due to the fact that the surgical incision to correct the scoliosis deformity is often large, these patients experience high bleeding and loss of high volume of the patient's blood volume requires blood transfusion. Increasing. Increased need for blood transfusions can lead to other postoperative problems and predispose these patients to postoperative complications; Therefore, the prediction and prevention of extensive blood transfusion is essential to improve the clinical outcome of patients. Therefore, in this study, we examine the changes in complete blood cell count in people who are candidates for scoliosis correction surgery over a period of 5 years. Methods: The sample of this study included 70 patients with surgical scoliosis who underwent scoliosis surgery in Shohada-Mahallati and Valiasr International Hospital in Tabriz in the period of 2015-2020. Gender, marital status, body mass index as well as surgery-related information including blood transfusion rate, duration of surgery, bleeding rate and duration of anesthesia were assessed. Also, red blood cell count, white blood cell count, blood platelet count, hemoglobin level, blood hematocrit level before surgery and up to 5 days after surgery were measured and evaluated. Results: The mean age of the sample was 24 18 18.43 years. In the sample, 65.7% were female and 34.3% were male. Examination of weight, height and body mass index showed that 58% of normal physical condition, 22% were obese and 20% were lean. The mean bleeding during the operation was 1213.89 ± 830 ml. In 85% of cases, blood transfusion was performed during surgery. Also, 30% needed blood transfusions after surgery. Intraoperatively infused blood was concentrated in 73% of erythrocytes and in 13% of both freshly frozen platelets and erythrocytes, and the mean total intraoperatively infused blood was 1098.6 ml. The results of linear regression showed that high weight (p = 0.007), low body mass index (p = 0.3) and high duration of surgery (p = 0.007) were significantly associated with high intraoperative transfused blood. The mean duration of hospitalization was 5.88 with a standard deviation of 2.1 days and the duration of hospitalization was positively and significantly related to the duration of surgery. Examination of the trend of changes in the variables of red blood cell count - platelet - hemoglobin and hematocrit showed that the day after surgery had a significant decrease compared to before surgery and this decrease continued until the third day after surgery. In all 4 variables mentioned, the decreasing trend changed after the third day and increased on the fourth day after the operation. The variable of white blood cells one day after surgery had a significant increase compared to before surgery, but from the second to the fifth day after surgery had a decreasing trend. The mean of variables 1 day after surgery was significantly different from before surgery (p <0.5).
5-year demographic data of patients with chronic thromboembolic pulmonary hypertension
(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Raeisnia, Khazar; Rashidi, Farid; Khezerloo Aghdam, Naser
Pulmonary hypertension due to obstruction in pulmonary artery because of chronic thromboembolism is classified in fourth group of all sorts of pulmonary hypertension. This disease causes heavy burden and affects the quality of life of patients. In addition, the prevalence of CTEPH is increasing and this can lead to an upsurge in mortalities. Main symptoms of CTEPH are dyspnea, activity intolerance, chest pain, edema and syncope. Materials and Methods: this is a retrospective cross sectional study of patients who referred to the pulmonary hypertension clinic of Imam Reza Hospital and were diagnosed with CTEPH. In order of collecting data a questionnaire containing all patients’ demographic information such as age, sex, history of deep vein embolism and thrombosis, clinical signs at the time of referral including dyspnea, chest pain, syncope and edema as well as patients’ hemodynamic findings was prepared. Also, echocardiographic findings performed by echo specialists and right heart catheterization data were gathered from recorded files. Results: from 91 patients of this study, there were 47 males (51.6%) and 44 females (48.4%). mean age at this study was 53.57 years. 45.1% of these patients had history of pulmonary embolism, 11% had history of DVT and 13.2% had history of both. Most frequent symptom was dyspnea that was seen in 90.1% of patients (mostly function class 3). Other symptoms were edema (18.8%), syncope (6.3%) and chest pain (6.3%). Mean 6MWD was 292.69. mean echocardiographic and hemodynamic statistics are mentioned above in table 4 and 5. 58.2% were operable and 37.4% were operated (PEA). Causes of not being operable were distal involvement, co-morbidities, no consent to surgery and not having symptoms. mean age in our study and most of other studies is above fourth decade of life. Chiefly patients have a history of thromboembolic specifically pulmonary embolism. As mentioned in this study 58.2% patients were operable. In our study and previous studies, the major reasons of not being operable were distal involvement and co-morbidities. PVR of CTEPH patients is increased due to obstruction.
5-year review of aural foreign bodies in pediatric, side effects and treatment outcomes
(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Haddad, S.; Jabbari Moghadam, Y.
Due to the high prevalence of children with complaints of foreign bodies in the ear, complications of lack of treatment or incorrect treatment, some complications can be prevented and also there is no similar study in domestic scientific databases and also in the country and due to lack of Necessary information in the field of epidemiology of this issue in the country, the present study was conducted with the aim of 5 years of examination of foreign bodies in children, complications and treatment results. Materials & Methods: In this retrospective descriptive study, patients who referred to Tabriz Children's Hospital with a complaint of a foreign body in the ear between April 2016 and March 2016 were reviewed. The records of patients subject to inclusion criteria were collected based on a checklist including the type of foreign body, subsequent side effects such as intraoperative findings and audiometric results, and the relationship between these two variables was examined. After collecting data, they entered SPSS software. In all tests, a significance level of 0.05 was considered. Results: In the present study, 165 children aged 1 to 12 years with a mean age of 5.36. 2.81 were included in the study. 103 (62.4%) were boys and 62 (37.6) were girls. There was a significant relationship between gender and foreign body of the ear so that the ratio of boys to girls was 1.66. The most common foreign objects were fruit kernels and cereals and plastic toys. The most foreign bodies in boys were the kernels of fruits and legumes and in girls the seeds were rosaries and pearls. The tympanic membrane was abraded in 93 cases (56.4%) healthy, 40 cases (24.2%) erythematous, 29 cases (17.6%) perforated and 3 cases (1.8%). In 38 cases (23%) blood was seen in the ear canal
The ability criteria –directed protocol versus emergency severity index and modified rapid emergency medicine score in triage of trauma patients
(Tabriz University of Medical Sciences, Faculty of Medicine, 2021) Jalilian Hamed, Hassan; Shams Vahdati, Samad; Khodayari, Mohamadtagi; Rajaei Gafouri, Rouzbeh
Background-With respect to high prevalence and high mortality of trauma in our country ,triage of patient trauma is very important. In basis of country protocol hospital emergencies use from five categories ESI(Emergency severity Index) in all of the country. The ideal triage criteria would be 100 percent accurate with no under triage or over triage ,however, this is not possible. We aimed to survey the ability criteria –directed protocol versus emergency severity index and modified rapid emergency medicine score in triage of trauma patients. Methods:This retrospective cross-sectional study was carried out on 120 patients admitted in Emergency department of Imam Reza hospital in 2020 where triaged by ESI and CDP .After study of patients we determine score of patients in basis of ISS and mREMS .If score of the patient more than 15 for ISS and more than 4-6 for mREMS ,the patient should be transmitted to CPR ,otherwise he or she under triaged. If score of patient lower than 15 for ISS and lower than4- 6 for mREMS the patient should be transmitted to trauma section ,otherwise he or she over triaged. American surgeon college advice maximum of under triage should not be more than 5 percent. In this study we calculated under triage 8.3percent and over triage 4.1 percent. Result :This study indicate ESI and ISS have direct connection in triage of patients. Also CDP and ISS have direct connection in triage of patients. ESI and mREMS have not direct connection with each other. CDP and mREMS have not direct connection and they are independent.
Abundance of Anxiety, Depression and Stress of vitiligo patients who referred to the dermatology clinic of Sina Hospital
(Tabriz University of Medical Sciences, Faculty of Medicine, 2019) Sasan, Marefat; Farhang, Sara; Gareh Aghaji Zare, Armaghan
Vitiligo is a relatively common acquired disorder of pigmentation characterized by the development of well-defined white macules on the skin that affects about 1% of the world's population. Although the cause of vitiligo is still unclear, several theories have been suggested, the autoimmune theory is the most acceptable. Due to the fact that the disease does not cause functional impairment, it is put in the category of aesthetic problems. Regard to previous studies on the psychological aspects of vitiligo, this study attempted to determine prevalence of Depression, Anxiety and Stress in vitiligo patients in northwest of Iran. Materials and Methods: A descriptive epidemiologic study on vitiligo patients who diagnosed by a dermatologist. The demographic data in each patient was recorded by self-administrated questionnaire. Persian translation of DASS-21 was used for diagnosis and determination of severity of Depression, Anxiety and Stress. Analysis of the data were done by SPSS version 22. Results: In this study, 105 patients were evaluated. Prevalence of Depression in women was 1.7 times to men, Stress in women was 1.1 times to men and the prevalence of Anxiety in men was 1.2 times to women. Among the age groups, prevalence of Depression was 66.6% in range of 20-29 years, Anxiety was 92.3% in range of 20-29 years and Stress was 100% in range of 20-29 years. Depression among university graduated patients was the most prevalent (74.2%), Anxiety among university graduated patients was the most prevalent (68.4) and Stress among high school graduated patients was the most prevalent (74.2%).
Abundance of foot and ankle pain and its determinant factors in the adults referred to the outpatient clinic of physical medicine and rehabilitation in 2020-2021
(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Samadi, Milad; Dolatkhah, Neda; Eftekharosadat, Bina
Foot pain is one of the most important factors that has a significant impact on mobility and health status of people. The purpose of this study was to determine the frequency of pain and disorders of the foot and ankle and its determining factors in adults referred to the outpatient clinic of physical medicine and rehabilitation in 2020-2021. Methods: The present study was a descriptive-analytical cross-sectional study. The target population was all adults 18 years and older referred to outpatient clinics of physical medicine and rehabiliting of Tabriz University of Medical Sciences. Sampling was done randomly and available and 460 people were selected. In this study, Foot and Ankle disability index was used to evaluate foot and ankle pain. Also, demographic-therapeutic information of patients was collected through a general profile questionnaire including personal information and medical information, through face-to-face interviews. Data were analyzed using non-parametric chi-square test (chi-square or chi-square) and Spearman correlation coefficient. Results: The sample of the present study included 460 adults referred to the outpatient clinic of physical medicine and rehabilitation in 1399, which in terms of gender included 384 women (83.5%) and 76 men (16.5%) and the average age of 57/08. The results showed that the three variables of education (p-value: 0.025), job (p-value: 0.001) and the need to use painkillers (p-value: 0.004) are factors related to foot and ankle disorders. The findings also showed that there was a significant relationship between age (p-value: 0.001) and body mass index (p-value: 0.001) with foot and ankle disorders.
Abundance of High intraocular pressure and Glaucoma in Patients with Uveitis in Tabriz Nikookari Eye Hospital in past 10 years
(Tabriz University of Medical Sciences, School of Medicine, 2019) Khodayari , Ata; Alizadeh Ghavidel, Leila; Mousavi, Farideh
The aim of the present study was to evaluate the abundance of glaucoma in patients with uveitis referred to Tabriz Nikookari Hospital in the past 10 years. Materials and Methods: Uveitis patients who had been diagnosed with glaucoma in the past 10 years and referred to the uveitis clinic of Nikookari Hospital during the year 2018 were studied. Required data were included age, patient gender, history of topical corticosteroid use. And systemic, anatomic location of uveitis including (anterior, middle, posterior and pan uveitis), esophagus (acute and chronic) and cause of uveitis (infectious, inflammatory), consumed corticosteroid (topical or systemic), interval from onset of uveitis to creation Glaucoma, primary vision and visual changes were recorded during treatment. Results: In the present study, 93 (21%) of 441 uveitis patients referred to uveitis clinic had glaucoma. The mean age of the patients was 43.5 years and most of the patients (62.4%) were female. The most common type of uveitis was related to diffuse uveitis (33.4%) and chronic (76.3%). Etiologically, 78% was non-idiopathic and 68.8% was non-granulomatous. The anterior chamber angle was open in 82.8%. 94.6% of patients received topical corticosteroids.The mean interval between uveitis and glaucoma was 2.13 years.
Abundance of Non Melanocytic Skin Cancer Surgeries in Outpatient Operation Room of Sina Hospital in 2017
(Tabriz University of Medical Sciences, Faculty of Medicine, 1398) Saeidi, Milad; Mostafidi, Elmira; Saniee, Sara
The aim of this study is to estimate the abundance of Non Melanocytic Skin Cancer surgeries in outpatient operation room of Sina hospital of Tabriz in 2017. Materials and Methods: In this study, which is a descriptive epidemiologic study, was studied information on the type of skin cancer based on pathology, age and sex of the patients, anatomical location of the skin lesions, the presence of lesion margin, the type of surgical technique and the size of the tumor recorded in the file and sample of all patients with skin cancer that was referred to Sina Hospital of Tabriz in 2017. Results: In this study, 277 patients underwent surgery and 338 NMSC surgeries were performed,242 patients undergoing surgery once and 35 patients undergoing various surgical procedures. The abundance of each tumor was respectively: 279 cases (82.5%) BCC and 45 cases (13.3%) SCC and 11 cases (3.3%) AK with severe dysplasia and 3 cases (0.9%) Bowen. Based on the surgical technique, 151 cases (44.7%) primary excision and 53 cases (15.7%) excision with secondary healing and 121 cases (35.8%) flap and 13 cases (3.8%) were graft. Based on the pathology, 309 cases (91.4%) were free margin and 29 cases (8.6%) had marginal involvement.
Abundance of Ocular Injuries Caused by Fireworks in “Charshanbe-Soori” Festival in Nikookari hospital , 2011-2016
(Tabriz University of Medical Sciences, Faculty of Medicine, 2019) Fani, Saeed; Ahour, Mohamad Hossein
Introduction: To describe abundance of ocular injuries caused by fireworks during the Persian Wednesday eve festival “Charshanbe-Soori” and to identify the fireworks devices involved . Materials and Methods: A cross-sectional study of consecutive patients referred to emergency room of Nikookari hospital due to fireworks-related eye injuries between 2011-2016 . All of patients who are interred to study in order to inclusion criterion and exclusion criterion will be studied . Severe trauma is omitted from the study . Patients information such as : age , gender , living place , place of occurrence , carrier , activity type , type of fireworks devices , type of trauma and treatment will be gathered and studied . Results Most of the patients were between 15 to 29 years old (41%) . 73.7 % were male , 40.2 % were students , 42.6 % had middle-school and high-school education , fire-crackers were mostly used (81.8 %) . 53.1 % were passerby . 66 % of injuries occurred in street . 94.3 % of people were living in the city . 13.9 % of injuries were bilateral . 70.8 % of injuries caused by blunt trauma . 84.2 % of cases treated as outpatient . There was no relation between any type of eye injuries with education , age , gender and firework devices .
Abundance of structural status of anterior Cerebral Complex at 20-30 GA fetuses during prenatal ultrasonographic screenings
(Tabriz University of Medical Sciences, Faculty of Medicine, 2020) Pashayi, Davood; Tarzamni, Mohammad Kazem; Ghojazadeh, Morteza; Ranjkesh, Mahnaz
Fetal ultrasonography is an important diagnostic tool in pediatric neurology. Study of the anterior complex, namely the cavum septum pellucidum. Methods: A total of 106 subjects with a gestational age of 20-30 weeks were included. They all underwent ultrasonographic examination and characteristics of the anterior complex were recorded. Results: In our study a total of 106 pregnant women were included, with 58 male fetuses and 48 female fetuses.The mean age of the women participating in the study was 29.7 ± 5.21 years old. In our study among the studied CSPs, 97 cases were rectangular (91.5%) and 9 cases were triangular (8.5%). The mean and standard deviation for the area in the rectangular CSP was 33.04±10.54 mm2 and in the triangular CSP was 21.05±4.18 mm2. In our study, the mean and standard deviation of length to width ratio of CSP was 1.98±0.31. In our study, the mean and standard deviation of length to width ratio of CSP was 1.98±0.31. In all cases where the CSP was triangular-shaped, the triangle's base was observed anteriorly (anterior based). In the implicit evaluation of the geometric dimensions and shape of the CSP with respect to the sex of the embryos examined, it was found that there was no clear relationship between the sex of the fetus and the geometrical shape of the cavum septum. Also, there was no significant relationship between sex of fetus and CSP Ratio.
Accessment of venouse impedance index and its relation with renal outcomes in patients with heart failure and renal dysfunction
(Tabriz University of Medical Sciences, Faculty of Medicine, 2020) Naderi, Samira; Ranjbar, Abdolmohammad; Zononi Vahed, Sepide; Ardalan, Mohammadreza; Tarzamani, Mohammad Kazem
In this study, we intend to examine the relationship between renal vein Doppler ultrasound and venous impedance index and its relationship with the type 2 cardiovascular syndrome proposal in the law of heart failure. Materials and Methods: All patients with chronic heart disease and acute renal failure who have proper forward function and most of them have passive congestion with the informed consent and after receiving permission from the ethics committee and research deputy who due to kidney failure by a nephrologist in Imam Reza Hospital They were visited in Tabriz and were introduced to the radiologist within 6 months after receiving the code of ethics and in coordination with the renal status and Doppler ultrasound, based on the indication, in order to calculate the venouse imprdance index along with the necessary measurements. Results: In this study, 49 patients were evaluated with the aim of venouse impedance index and its relationship with the outcome of patients with heart failure and decreased renal function. In this study, 42.9% of patients were female and 57.1% were male. Mean age of patients was 61.83±12.39 The mean duration of heart failure was 33.16 ± 23.86 months and the mean duration of renal failure was 11.76. ± 11.92.
Accuracy of NanoBiosensor-based Molecular Assays for Diagnosis of COVID-19 Compared to RT-PCR as a Reference Test: a Systematic Review
(Tabriz University of Medical Sciences, Faculty of Medicine, 2023) Shirvaliloo, Milad; Safiri, Saeid; Bannazadeh Baghi, Hossein; Ahmadpour, Ehsan
Nanobiosensors (NPBs) are biosensing platforms that incorporate nanomaterials for robust detection of biologic particles, and can be applied for clinical diagnosis of COVID-19 with acceptable accuracy. We sought to evaluate the diagnostic accuracy of NPBs as an emerging alternative to RT-PCR in the clinical identification of SARS-CoV-2. Our aim was to systematically synthesize evidence to justify the diagnostic value of NPBs as a suitable replacement for RT-PCR in the clinical identification of the novel coronavirus. Methods: We searched seven literature databases including EBSCOhost Web, Embase, ProQuest, PubMed/MEDLINE, Scopus, Web of Science, and WHO LitCOVID to identify original records concerned with development and application of NPBs in the clinical diagnosis of COVID-19 that were published from November 1, 2019 to April 30, 2022. We then calculated the indicators of diagnostic power including sensitivity, specificity and accuracy. As part of a joint clinical investigation, we collected a total of 72 saliva specimens 24 age-matched patients with RT-PCR-confirmed COVID-19 on days 1, 3 and 5 following their hospitalization, which were tested using the rapid antigen diagnostic kit for SARS-CoV-2. Results: We included 13 studies that reported original findings regarding the use of different NPBs in the clinical identification of COVID-19 via molecular identification of viral surface proteins and RNA in NPS/OPS. In total, 789 NPS/OPS samples gathered from 376 COVID-19+ and 413 COVID-19– participants were surveyed by the included studies using a total of 13 distinct NPBs. Compared to the reference test or RT-qPCR, NPBs yielded a mean sensitivity of 97.07%, a mean specificity of 94.43% and a mean accuracy of 96.91%. As for the clinical investigation, saliva-based test using rapid antigen kits conferred mean accuracy rates of 83.3%, 58.3% and 62.5% on days 1, 3 and 5, respectively.
The activity of different brain regions in fatigued and drowsy drivers: A systematic review based on EEG findings
(Tabriz University of Medical Sciences, Faculty of Medicine, 2023) Norouzi, Ali; Ghojazadeh, Morteza; Farahbakhsh, Mustafa
Drowsiness and fatigue during driving is one of the major causes of traffic accidents, morbidity, and mortality in societies. Known EEG as a gold standard in fatigue detection, this study aims to determine the alterations in different brain regions in fatigued and drowsy drivers. Materials and Methods: The databases PubMed, Scopus, Web of Science, and Embase have been systematically searched for published studies until September 1st, 2023. Also, the references of the relevant articles have been searched manually. Reporting the quality assessment of the studies has been done by the Johanna Brigs Institute (JBI) critical appraisal tool for experimental studies. The study purpose was achieved using appropriate statistical methods. Results: Sixty-five eligible studies consisting of 1450 participants. The most common age and gender between participants is young males. The majority of the studies were held in High-Income countries. Simulated car driving studies are utilized frequently in the studies. Common brain-wave changes seen in various regions include increased alpha in the occipital area (51.7%) and decreased alpha in the frontal region (eight out of eight simulated driving studies), decreased beta in the frontal region (25.8% of driving simulated studies), increased theta in the frontal region (36.2%), and decreased gamma in the central and temporal areas. Delta waves increase throughout the brain in an equal proportion.
Acute Primary closed angle glaucoma in emergency department of Tabriz Nikukari Ophthalmology Center from 2007 to 2016, Causes and outcomes
(Tabriz University of Medical Sciences, Faculty of Medicine, 2019) Alizadeh, Sajjad; Daei Sorkhabi, Rana; Mahdavi fard, Ali
In this study, we decided to address the causes and outcome of the treatment of cases of acute Closed-angle glaucoma who visited the Emergency Department of Tabriz Nikukari hospital. Materials and Methods: This descriptive cross-sectional study was conducted on hospital records with the aim of investigating the causes and outcomes of acute Closed-angle glaucoma in the emergency department of Tabriz Nikukari Ophthalmology Center from 2007 to 2016. In this study, 61 patients were enrolled. This study was performed on patients referred to the Emergency Department of the Nikukari Hospital of Tabriz University of Medical Sciences from 2007 to 2016. Results: The average age of patients in our study was 57.13 ± 2.35. The average intraocular pressure before and after treatment was 49.93 ± 1.44, and 96.9 ± 0.8, and one week after treatment it was 15.65 ± 0.62. The intraocular pressure was reduced after treatment. 36 patients were without underlying illness (59%) and 25 patients (41%) had an underlying illness. There was no relationship between this history and intraocular pressure immediately after treatment and one week after treatment. However, there was a significant statistical relationship between intraocular pressures. 40 patients were without previous history of glaucoma (65.6%) and 21 patients (34.4%) had previous history glaucoma treatment.
Adaptation of COVID-19 Stress Scale (CSS-19) in Iran
(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Nikjoo, Amin; Heydari, Fariba; Norouzi, Sanaz
In addition to physical consequences and high mortality rate of Covid19, its psychological and social consequences have also been subject to many studies around the world. Numeral tools having been developed for this purpose; CSS-19 is one of the most cited scales. Considering the lack of a validated and reliable tool for assessment of psychosocial aspects of Covid19 in Iran, we conducted this study to adapt CSS-19 so it is suitable to be used in Iran. Methods and Materials: After Forward-Backward translation to Farsi, the questionnaire was both qualitatively and quantitatively assessed by the experts panel regarding content, construct and face validity. Then the modified Farsi CSS was filled by 50 participants twice with a 2-week interval in order to assess reliability and consistency. Results: Based on the opinions of experts panel, 16 items were deleted from Farsi CSS, including all items of Xenophobia subscale, for it to be suitable for Iranian society. Then the modified 20-item Farsi CSS was assessed by a second experts panel, which confirmed its validity. Finally, our statistical analysis showed a Cronbach`s Alfa of 0.91 and 0.88 and ICC of 0.98 for the 20-item Farsi CSS.
AdeB efflux pump gene knockdown by mRNA mediated peptide nucleic acidin multidrug resistanceAcinetobacter baumannii
(Tabriz University of Medical Sciences, Faculty of Medicine, 2020) Abdi, Seyed Naser; Asgharzadeh, Mohammad; Bannazadeh Baghi, Hossein; Hasani, Alka; samadi kafil, Hossein; Ghotaslou, Reza
Multidrug-resistant Acinetobacter baumannii isolates cause critical problems in health-care environments. AdeABC is a resistance-nodulation-cell division (RND)-type multidrug efflux pump conferring resistance to clinically essential antibiotics in A. baumannii, such as ciproﬂoxacin. This study aimed to target adeB gene with antisense peptide nucleic acid (PNA) and investigate its effect on resistance to antibiotics. NCBI database was used to design appropriate PNA to target adeB gene, by connecting PNA to mRNA, the translation of mRNA can be prevented. Three clinical isolates and A. baumannii ATCC 17978 were treated with the designed PNA by electroporation and competence procedure. Minimum Inhibitory concentration (MIC) of ciproﬂoxacin, colistin, and tetracycline were determined by microbroth dilution method. In addition, the expression level of adeB gene was measured by quantitative real-time PCR (qRT-PCR). Isolates used in this study had mutations in gyrA and parC genes corresponding to resistance to ciproﬂoxacin. MIC of resistance to ciproﬂoxacin after treatment with PNA was reduced from 32μg/ml to16μg/ml in A. baumannii ATCC 17978 isolate. Susceptibility level of tetracycline, in the 2 clinical isolates was decreased from 64μg/ml to 32μg/ml and in the other isolate was reduced from 128μg/ml to 64μg/ml. The expression level of adeB gene was decreased in A. baumannii ATCC 17978 (P > 0.01) but not in clinical isolate (P=0.107). Findings of the present study indicate overexpression of adeB efflux pump has extra effect on resistance to antibiotics in isolates with a deﬁned mechanism of resistance. Antisense technology is a feasible technique to suppress the function of these genes, which may be further exploited to control multidrug-resistant isolates.
Adherence to diagnostic and treatment covid-19 guideline in outpatient care: viewpoints of medical Interns in Tabriz University of medical sciences
(Tabriz University of Medical Sciences, Faculty of Medicine, 2022) Saeedifar, Sasan; Baradarane Binazir, Maryam
Due to hospital beds limitation and widespread Covid19 pandemic, outpatient diagnostic and therapeutic procedures are one of the requirements of health centers related to Covid19. Necessity of outpatient diagnose and treatment in health centers are abundant some examples of that are as follow
Admission Electrocardiographic findings for estimation of early outcome after discharge in acute heart failure patients
(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Mirkazemian, Ehsan; Chenaghlou, Maryam; Abbasnezhad, Mohsen
Heart failure, re-hospitalization, and mortality are the main problems in the field of cardiology. Among the things that can help us in determining the prognosis of these patients are the findings of the cardiogram; For this purpose, in this study, it has been tried to evaluate the relationship between ECG findings and re-hospitalization and mortality one month after discharge. Methods: This cross-sectional study was conducted from January 2023 to January 2024 at Shahid Madani Hospital in Tabriz, and patients hospitalized with new onset, or decompensated heart failure were included in the study. The clinical information of the patients including age, sex, cause of heart failure, underlying diseases, medications, laboratory findings, and echocardiography ECG findings as well as one-month follow-up were recorded and the recorded data were analyzed to find the relationship with early prognosis determination in these patients. Results: ECG findings such as ST Elevation with (P-Value: 0.04) and Pace Maker Rhythm with (Odds Ratio: 8.91) can predict readmission one month after hospital discharge in patients with acute heart failure. ECG findings were not significantly related to early mortality in patients with acute heart failure.
Admission renal function and electrolyte levels for estimation of total diuretic dose in acute heart failure patients
(Tabriz University of Medical Sciences, Faculty of Medicine, 2024) Valizadeh Khoushehmehr, Mina; Chenaghlou, Maryam; Aslanabadi, Naser
Heart failure is one of the major challenges in the healthcare system. Hospitalizations are a primary concern for these patients, imposing significant burdens on both the patients and the healthcare system. Identifying the factors that influence better management of these patients is crucial, as it can help reduce the overall disease burden. Typically, congestion is the primary issue in hospitalized heart failure patients, and the main treatment involves loop diuretics. Estimating the necessary diuretic dosage is important for better management of these patients. The aim of this study is to evaluate renal function and electrolyte levels at the time of admission to estimate the required diuretic dosage in patients hospitalized with acute heart failure. Methods and Materials: This study is a descriptive cross-sectional study with a prospective approach conducted in 2023. It included all patients diagnosed with acute heart failure who were admitted to Shahid Madani Hospital (affiliated with Tabriz University of Medical Sciences) through a complete census. All patient information, including age, gender, cause of heart failure, underlying conditions, medications used, laboratory findings, echocardiographic results, medications administered during hospitalization, and the total dose of furosemide administered, was recorded. The relationship between renal function and electrolyte levels at the time of admission with the total dose of furosemide prescribed during hospitalization was evaluated using regression methods, leveraging artificial intelligence and machine learning techniques. Results: In this study 250 patients with heart failure with mean age of 65/18±13.8 years and 65%of them were men. In these patients, the mean serum BUN level was 24/73±11/08 mg/dl and the mean total dose of furosemide was 540/88±223/46 mg. There was a significant relationship between BUN and the total dose of furosemide (P=0.033).