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  •   صفحه اصلی مخزن دانش
  • School of Medicine
  • Theses(M)
  • مشاهده آیتم
  •   صفحه اصلی مخزن دانش
  • School of Medicine
  • Theses(M)
  • مشاهده آیتم
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Relationship Between Bacterial Septicemia with Gut Microbiota and Major Antigens of ABO Blood Group

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تاریخ
2023
نویسنده
Nabizadeh, Edris
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نمایش پرونده کامل آیتم
چکیده
Sepsis is a complex clinical disorder with various etiological factors. This problem is considered a global health issue, because the consequences of sepsis are unfavorable and the mortality rate is high. In recent years, the relationship between gut microbiota, their metabolites and major antigens of ABO blood group in the pathophysiology of sepsis has been reported. Scope: The aim of this study was to investigate the members of the intestinal microbiota, their metabolites, as well as the relationship of the main antigens of blood groups in non-ICU patients with sepsis compared to the control group. Methods and materials: In this case-control study, 45 stool samples from non-ICU patients with sepsis and 15 healthy individuals with specific blood groups were collected from October 2021 to August 2022 from Imam Reza and Sinai hospitals. The members of intestinal microbiota were evaluated using real-time PCR method and short chain fatty acids (acetic, propionic and butyric acid) as the main metabolites of intestinal microbiota were measured using HPLC high-performance liquid chromatography system. Results: The relative number of bacteria with a protective role, including Faecalibacterium prausnitzii and Bifidobacterium spp, as well as the concentration of acetic acid and propionic acid in non-ICU patients with sepsis compared to the healthy group was significantly reduced. On the contrary, the relative number of members of pathogenic bacteria such as Enterobacteriaceae and Bacteroides species was significantly increased in patients compared to healthy individuals. Butyric acid concentration decreased in patients, but this change was not significant. Also, no significant relationship was observed in connection with blood group antigens and members of the studied microbiota.
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https://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/71162
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  • Theses(M)

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مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
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