IL-6 gene expression level patients with Palindromic Rheumatism

Abstract

Palindromic Rheumatism is characterized by irregular and recurrent attacks with arthritis and periarthritis without fever. Considering the proven role of IL-6 axis genes in the pathogenesis of rheumatic diseases and the significant prevalence of palindromic rheumatism and the significant risk of palindromic transformation of rheumatism to rheumatoid arthritis, the aim of this study is to investigate the expression level of IL-6 axis genes in patients with palindromic rheumatism. Method: In this cross-sectional study, blood samples were taken from 17 patients with palindromic rheumatism, 35 patients with rheumatoid arthritis and 38 patients as a control group in Imam Reza Hospital. Then the blood plasma of patients and healthy people was separated and used to measure the amount of cytokines by ELISA. Statistical analysis was done by SPSS version 16 software and the significance level in this study was considered P<0.05. Results: it can be seen that the IL-6 serum levels in the studied groups, including palindromic rheumatism and rheumatoid arthritis, were different from the control group, which indicated that this factor probably plays a role in the pathogenesis of palindromic rheumatism. Considering the proven role of IL-6 in the pathogenesis of rheumatic diseases and the significant prevalence of palindromic rheumatism and the risk of turning palindromic rheumatism into rheumatoid arthritis, the aim was to investigate the expression level of IL-6 genes in palindromic rheumatism patients. It should also be mentioned that the present study is the first study that investigated the serum level of IL-6 in people with palindromic rheumatism and its relationship with the severity of pathogenesis and clinical characteristics, based on the results of a significant correlation between the serum level IL-6 and its level of expression showed in patients with palindromic rheumatism, but no significant difference was seen in the serum levels of these two factors according to active and inactive disease in the studied subjects.