• English
    • Persian
    • English
    • Persian
  • Persian 
    • English
    • Persian
    • English
    • Persian
  • ورود
مشاهده آیتم 
  •   صفحه اصلی مخزن دانش
  • School of Advanced Medical Sciences
  • Theses(AMS)
  • مشاهده آیتم
  •   صفحه اصلی مخزن دانش
  • School of Advanced Medical Sciences
  • Theses(AMS)
  • مشاهده آیتم
JavaScript is disabled for your browser. Some features of this site may not work without it.

Association of advanced glycation end-products (AGEs) with embryo morphokinetic parameters and assisted reproductive techniques (ART) outcomes.

Thumbnail
نمایش/بازکردن
chapter 1,2,3,4,5 (Final...).docx (5.073Mb)
تاریخ
2024
نویسنده
Roushenas, Fatemeh
Metadata
نمایش پرونده کامل آیتم
چکیده
Background and aims: Advanced glycation end products (AGEs) can disrupt antioxidant system and steroidogenesis, resulting in detrimental effects on assisted reproductive technology (ART) outcomes. This study aimed to investigate the association of AGEs in follicular fluid (FF) with morphokinetic parameters of embryos and ART outcomes. Materials and methods: Fifty women undergoing ART treatment were studied. AGEs, glucose, 25(OH) vitamin D, malondialdehyde (MDA) levels and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities were evaluated in FF. The expression of 3βHSD, CYP11A1, and CYP19A1 genes were analyzed in granulosa cells (GCs) by qRT-PCR technique. Morphokinetic parameters were evaluated using time-lapse technology. Results: The FF level of AGEs was reversely associated with CAT, SOD, and GPX activities, and total and mature oocytes number, blastocyst formation rate, and high-grade embryos number, while it showed positive correlations with the FF MDA levels, the expression of steroidogenesis genes, number of immature oocytes, morphokinetic parameters, and number of low-grade embryos. Furthermore, the level of vitamin D in FF had an inverse association with AGEs and positive correlations with ART outcomes and morphokinetic parameters. Comparison between the those with positive and negative biochemical pregnancy showed no significant differences in terms of FF factors and just the expression of 3βHSD, CYP11A1, and CYP19A1 genes were higher in non-pregnant women (p < 0.05). Conclusion: AGEs could delay blastomere division and lead to an increase in the number of low-quality embryos, while vitamin D have an adverse effect on AGEs and a protective function against AGEs negative effects.
URI
https://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/70817
Collections
  • Theses(AMS)

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV
 

 

مرور

همه مخزنجامعه ها و مجموعه هابراساس تاریخ انتشارنویسنده هاعنوانهاموضوعاین مجموعهبراساس تاریخ انتشارنویسنده هاعنوانهاموضوع

حساب من

ورودثبت نام

مخزن دانش دانشگاه علوم پزشکی تبریز در نرم افزار دی اسپیس، کپی رایت 2018 ©  
تماس با ما | Send Feedback
Theme by 
Atmire NV