Comparing the effectiveness of Chicoridin, Brewers yeast and Cyproheptadin on weight gain of male mice

Abstract

introduction: Chronic thinness is a physiological and sometimes pathological condition that needs investigation and treatment. Several factors such as genetics, high metabolism rate, poor nutrition, and physical or mental illnesses can cause weight loss. Drugs include cyproheptadine, chicoridine and brewer's yeast may play a role in increasing appetite and weight. These drugs have previously had good effects on weight gain separately, but so far they have not been used in combination with each other.Objectives: The current research tries to evaluate the effectiveness of these drugs in weight gain and also measure their metabolic side effects.Methodes: 72 male mice were divided into 9 groups and received cyproheptadine, chicoridine and brewer's yeast separately and in combination for 28 days. Food and water consumption and blood sugar were measured every 3 days. At the end of the 28 day period, blood is taken from the heart of the mice to check the lipid profile.Result: Cyproheptadine and chicoridine alone and in combination with each other, unlike brewer's yeast, could increase appetite and weight. Also, chicoridin alone and in combination with brewer's yeast significantly reduced blood sugar. Brewer's yeast could not have a good effect on any of the measured factors.conclusion: cyproheptadine and chicoridine can be an option to increase appetite and weight. The best effectiveness is observed when these two drugs are used in combination with each other. Brewer's yeast could not have a good effect on increasing appetite, weight and reducing blood sugar and improving lipid profile.