Evaluation of the effect of uterine flushing with hCG on biochemical and clinical pregnancy rate in the IUI cycle of couples with idiopathic infertility
چکیده
Although assisted reproduction technology (ART) success has been
improved almost 30% of infertile couples worldwide are diagnosed with
unexplained infertility. The study objective was to evaluate the pregnancy rates
among primary unexplained infertile ladies who were affiliated with intra uterine
hCG injection at the time of the hCG trigger in comparison with hCG trigger alone.
Methods: A parallel randomized controlled trial was conducted involving 80 ladies
with primary unexplained infertility at Al-Zahra Referral Academic Center.
Participants were randomly allocated into two groups (40 subjects in each group).
The intervention group received 1000 IU HCG diluted in 0.5 cc normal saline
injected directly in uterus plus two intermuscular ampoules (5000 IU) of human
chorionic gonadotropin (hCG) while the control group received only intermuscular
hCG using intrauterine insemination (IUI) after 34-36 hours triggering to improve
the pregnancy rates.
Results: There was no significant relation between-groups regarding demographic
and clinical characteristics such as endometrial thickness, and the number of
follicles before intervention (p>0.05). The clinical pregnancy proportion was 32.8%
(13/40) in hCG group versus 33.3% (13/40) in the intra uterine hCG group;
(p=0.954). While chemical pregnancy rate was 32.8% (13/40) versus 33.3%
(14/40). No significant associations were found for biochemical pregnancy and the
number of gestational sacs (p=0.954).