Prediction of liver enzymes for Pre- hypertension and hypertension in Azar cohort population

Abstract

There is a reciprocal relationship between liver dysfunction and the development of hypertension. Liver enzymes alanine and aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase are indicators of liver health. Considering the importance of the mentioned contents,; We investigate which of the liver enzymes are better predictors for prehypertension and hypertension in the population of Azar cohort. Research materials and methods: In this cross-sectional study that was conducted among the Azar cohort population (15,000 people aged 35-70), a checklist including age, sex, marital status, education level, smoking status, family history of high blood pressure, blood pressure level Blood and liver enzymes were evaluated. Then the relationship and prediction of liver enzymes for prehypertension and hypertension were determined. Then, multivariate logistic regression analysis was used to identify predictors of blood pressure. Results: In this study, 6062 hypertensive patients, 844 prehypertensive patients and 8086 healthy individuals were examined as a control group. After removing the confounding variables of age, sex, education level and weight, the level of liver enzymes (AST (for pre-hypertension (OR: 1.14; 1.05-1.23)) for hypertension (OR: 1.27; 1.17-1.37)), ALT (for pre-hypertension) Hypertension (OR: 1.37; 1.26-1.48) for hypertension (OR: 1.58; 1.46-1.72) ), ALP (for prehypertension (OR: 1.35; 1.24-1.47) for hypertension (OR: 1.85; 1.71-2.01) ), GGT (for prehypertension (OR: 1.60; 1.48-1.74) for hypertension (OR: 2.00; 1.84-2.17)) was significantly higher in prehypertension and hypertension patients than in the control group (P<0.05).