Assessment of Ganglion cell layer in different age groups

Abstract

The ganglion cell layer (GCL) is a thin layer of cells in the retina that transmits visual stimuli to the brain. This layer plays a role in many eye diseases, including glaucoma, age-related maculopathy, cataracts, diabetic retinopathy, and temporal arteritis. Measurement of GCL thickness using optical coherence tomography (OCT), an important tool in ophthalmic research. Research in this field helps improve the understanding of the aging process and age-related biological phenomena. Methods and Materials: This descriptive-analytical cross-sectional study was conducted at Nikokari Hospital in Tabriz. Two hundred individuals (forty individuals in each age group) were randomly selected from the hospital database. The inclusion criteria were a history of retinal-related eye diseases. The OCT data of the participants were extracted and entered into SPSS for analysis.ANOVA test was used to investigate the relationship between age and the thickness of the ganglion cell layer. LSD method was also used for post hoc analysis. Results: In the overall comparison, there was no significant difference between different age groups in each section of this layer according to the ANOVA test results. However, in the post hoc analysis, a reduction in the parafovea parts of this layer was observed in ages after 31-40 years