The effect of date seed powder supplementation on nutritional, metabolic and oxidative stress in type 2 diabetes patients

Abstract

Results: Based on the results obtained from data analysis, daily supplementation with 5 grams of date seed powder for 8 weeks led to a significant reduction in insulin, hemoglobin A1C, insulin resistance, total cholesterol, triglycerides, LDL-c, and malondialdehyde, as well as a significant increase in insulin sensitivity and total antioxidant capacity compared to the placebo group (p<0.05). However, changes in fasting blood glucose and HDL-c levels were not significant (p>0.05). Date seed powder supplementation also resulted in a significant decrease in energy intake, carbohydrate, fat weight, and BMI compared to the placebo group. Conclusion: In general, the results of this study indicate that the consumption of date seed powder may assist in controlling and preventing type 2 diabetes by improving glycemic indices (except fasting blood glucose), lipid profiles (except HDL-c), and oxidative stress. Therefore, date seed powder could potentially be introduced as a healthy and cost-effective antioxidant supplement for type 2 diabetic patients alongside their prescribed medications. Keywords: Date seed powder, glycemic indices, oxidative stress, lipid profile, type 2 diabetes, polyphenols