Association between oxygenation and ventilation indices with duration of mechanical ventilation in children 2 months to 14 years old admitted to PICU

Abstract

To evaluate the correlation between oxygenation and ventilation indices in predicting the duration of mechanical ventilation in children aged two months to 14 years old admitted to PICU Materials & Methods: In this cross-sectional study, 56 patients were included in the present study. The required information was extracted from the patients' clinical records including age, sex, diagnosis, duration of intubation, extubation time, mechanical ventilation parameters, blood gas parameters and entered into the prepared questionnaires. Patients' blood and ventilation data were collected and calculated from the first day of mechanical ventilation until 7 days later to calculate oxygenation (OI) and ventilation (VI) indices. The results have been statistically analyzed. Results: Pneumonia, the most common cause of hospitalization in the intensive care unit and the need for intubation, was present in our population (82%) due to aspiration and Covid-19 disease. There was a significant relationship between higher levels of FiO2 and longer duration of patients' intubation. (P <0.001) The amount of PIP in each of the first days of intubation was significantly correlated with the duration of the study. In statistical analysis of the correlation between ventilation index and oxygenation index, a significant direct relationship was found. (P <0.05) In examining the relationship between oxygenation index and duration of intubation, except on the sixth day, a significant relationship was observed. (P <0.05) This means that statistically, with increasing oxygenation index, the duration of intubation was longer. In examining the relationship between ventilation index and duration of intubation, except on the fourth and fifth days, a significant relationship was observed. (P <0.05) This means that statistically, with increasing ventilation index, the duration of intubation was longer. None of the extubated patients required re-intubation. In examining the effect of intubation period on the final result in the form of discharge and recovery of the patient or his death, there was a statistically very weak relationship.