| dc.description.abstract | Atherosclerosis is one of the leading causes of cardiovascular diseases. In this study, the association of serum levels of pro-inflammatory markers interleukin (IL)-1β and IL- 10, C-reactive protein (CRP), cyclooxygenase-2 (COX2), High-density lipoprotein (HDL), Apolipoprotein A1(ApoA1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins with atherosclerosis index (homocysteine) in normal-weight and obese male subjects was assessed.
Methods: 59 males including 30 obese (Body mass index (BMI) of ≥ 30 kg/m2) and 29 normal-wight (BMI of 18.5-24.9 kg/m2) were joined to this study. Plasma levels of IL-1β and IL-10 (pg/ml), CRP (pg/ml), COX-2 (ng/ml), APOA1 (mg/dl), ABCA1 (ng/ml), HDL, Cholesterol, and Triglyceride (TG) (mg/dl), and homocysteine (µmol/l) was measured with Real Time PCR. Association of these biomarkers with homocysteine was determined via Spearman and Pearson correlation.
Results: Obese subjects had higher serum levels of IL10, IL1β, CRP, COX-2, TG, and cholesterol concentrations (all p<0.05 except IL-10 and cholesterol) and low levels of HDL, APOA1, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with APOA1, ABCA1, and HDL, and a strong and moderate positive correlation was found with CRP and TG levels, respectively. | en_US |
