Correlation between serum Salusine beta level with clinical presentation and activity of Lupus disease

Abstract

Lupus is a chronic multisystem autoimmune disorder of unknown cause that is associated with the production of antibodies and immune complexes against various tissues in the body. The aim of this study was to evaluate the serum level of salosin beta with clinical manifestations and activity of lupus. Methods: In the present cross-sectional study, 60 lupus patients diagnosed by a rheumatologist along with 30 healthy individuals as a control group who were the same age and sex as the patients were studied. In the study group, clinical and demographic information were recorded after clinical examination and the activity index and disease severity were calculated. Serum levels of salosin beta along with serum levels of complement and dSDNA antibody were measured and compared and statistically analyzed for both control and patient groups. Results: The results of the present study indicate that there is a significant difference between serum salosin beta levels in patients and controls (p = 0.001). Serum salosin beta level was significantly higher in patients with renal involvement (p = 0.001). There was also a significant difference between patients with and without pulmonary involvement (p = 0.013). This difference is also significant in patients with and without thrombus (p = 0.002). Also, a positive and significant correlation was observed between salicyin beta level and complications and renal involvement class (p = 0.001, r = 0.544).