Follicular delivery of Urtica ethanolic root extract-loaded nanoliposome and its performance assessment in animal models

Abstract

Abstract: Androgenetic alopecia (AGA) is a disorder that involves gradual loss of hair in genetically predisposed individuals and is more prominent in men than women.Physiological changes which occur during AGA include hair follicle miniaturization and variations in normal hair cycle; specifically, anagen phase length shortens and that of telogen phase stays same or prolongs.An array of different factors including heredity, androgenic hormones, microinflammation of hair follicles and scalp, infections, nutritional deficiency and harsh environmental conditions. Minoxidil (useful in both male and female pattern baldness) and Finasteride (useful in male pattern baldness) are two US FDA-approved synthetic drugs finding concomitant use for treatment of androgenic alopecia.The side effects associated with the use of these synthetic compounds include erythema, scaling, pruritus,gynaecomastia, dermatitis, itching or skin rash. Urtica dioica L. is a common plant in the world. It has become a source of folk medicine for the treatment of many diseases. The leaves and roots are both used internally as a blood purifier and diuretic and an infusion of the plant is used for nasal and menstrual haemorrhage, diabetes, rheumatism, eczema, anaemia, as an expectorant and hair loss. Now we want to examine the effect of Urtica dioica root extract loaded liposome on mice C57BL/6.