Effect of Oxytocin Infusion on Irrigation Fluid Absorption during Hysteroscopic Myomectomy

Abstract

Uterine leiomyomas are the most common benign tumors in women. Myomas are present in more than 25% of women over 35 years of age. Today, the main treatment for these benign tumors is the use of hysteroscopic myomectomy. The aim of this study was to investigate the effect of oxytocin infusion on the absorption of irrigating solution in patients undergoing hysteroscopic myomectomy. Materials and Methods: In this double-blind and randomized clinical trial, 50 patients aged 25-45 years with ASA class I or II physical status and scheduled for hysteroscopic myomectomy were studied. In the study group (n=25) 15 units of oxytocin were infused in 250 ml of ringer serum at a rate of 125 ml / h and in the placebo group (n=25) 1.5 ml of normal saline was added to the same volume of ringer solution and administered at the same rate. Hemodynamic changes during procedure, Fluid deficit, decreased of Hb, Hct, plasma sodium and albumin values from base, intra-operative complications of study solutions and irrigating fluid toxicity were assessed intraoperatively and 24 hours postoperatively. Results: The amount of consumed irrigation fluid (p=0.032) and deficit fluid (p=0.034) was significantly lower in the study. The frequency of intraoperative decreased of blood pressure was significantly lower in the oxytocin group than the placebo group (12% vs 24%; p=0.019). The amount of decreased in Hct (p=0.43) and plasma sodium (p=0.026) were significantly lower in the study group than the placebo group.