Relationship between Vitamin D serum level and ST resolution after Primary PCI in patients with acute myocardial infarction

Abstract

Lower vitamin D levels are associated with a higher incidence of ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the role of vitamin D2 on the resolution of ST-segment elevation (STE) after a primary percutaneous coronary intervention (PCI). Methods: All patients who underwent PCI for STEMI were screened for enrollment. Vitamin D2 levels were measured on admission along with other biochemical and hematologic assays. The electrocardiography (ECG) was recorded upon arrival and 60 minutes after the completion of PCI. The study's primary endpoint was a ≥50% resolution of ST-segment amplitude (+STR) compared to the initial ECG. A logistic regression multivariate analysis was performed to examine the association of STR with all confounding variables, including the admission levels of vitamin D. Receiver-operator characteristics analysis was used to determine the cutoff value of vitamin D that was predictive of STR. Results: Although there was no difference in STR based on standard classification of vitamin D sufficiency, critically low levels of vitamin D (≤7.5 ng/mL) were significantly associated with the absence of STR after PCI (AUC was 0.65±0.07; P<0.001). Critical deficiency of Vitamin D was a moderate predictor of STR in these patients with a sensitivity of 86% and 54% specificity.