Study of the Concentration of Stool Calprotectin in Children with Cystic Fibrosis

Abstract

The aim of this study was to evaluate the FC level in patients with CF and its relationship with various factors such as disease severity. Methods: 52 children with cystic fibrosis were enrolled in the study and data such as age, sex, weight, age at diagnosis, pancreatic insufficiency, respiratory symptoms, and pulmonary infections and respiratory failure were recorded. Also, fecal calprotectin level was measured by ELISA in all patients. Then, the correlation between fecal calprotectin level in patients with each of the above cases was evaluated. Results: The mean age of the patients was 8.85±5.05 years and at the time of diagnosis were 13.49±3.4 months. Mean FC of patients was 60.32±34.53 µg / dl. 22 patients (42.3%) had normal FC and 30 patients (57.7%) had higher FC than normal. 95.5% (21) of patients with normal FC and 100% (30) of patients with abnormal FC had pancreatic insufficiency (P=0.42). The frequency of exacerbation in patients with normal FC was 2.13±0.74 and in patients with abnormal FC was 5.56±8.67 times (P = 0.08). FEV1 in patients with normal FC was 82.38 9 9.53% and in patients with abnormal FC was 78.14±13.67% (P = 0.25).