Study of the Effect of Silymarin on Haloperidole-Induced Catalepsy and Motor Imbalance in Male Rats

Abstract

Introduction: The effect of silymarin against oxidative stress is reduced by inhibiting free radicals, activating superoxide dismutase and increasing glutathione. Aim: Study of the effect of Silymarin on Haloperidole-induced catalepsy and motor imbalance in male rats Experimental: 5-day intraperitoneal injection of haloperidol at a dose of 1 mg / kg was used to induce catalepsy. On the fifth day, catalepsy and motor balance were assessed using bar test and rotarod. Silymarin injected in three groups in addition to daily injection of haloperidol received silymarin every day in the doses mentioned above and on the fifth day as in the previous groups catalepsy and motor balance Were examined in them. Results: In the present study, haloperidol injection caused a significant increase in bar test time compared to the control group. haloperidol injection significantly reduced rotarod test duration, which indicates The effect of haloperidol on imbalance in male rats. In the present study, silymarin at a dose of 25 mg / kg did not have a significant effect on improving catalpsis, but at doses of 50 and 100 mg / kg had a significant effect on increasing bar test time and reducing rotarod test time, which indicates The effective effect of 50mg / kg and 100mg / kg doses on catalepsy and motor imbalance caused by haloperidol. Conclusion: haloperidol causes catalepsy and motor imbalance in male rats. Injection of 50 and 100 mg / kg silymarin improves catalepsy and motor imbalance in these animals. Silymarin was also shown to cause Increases serum TAC and decreases MDA at high doses.