Comparison of the Result of Interlukin-6 in Maternal Serum with Cervicovaginal Fluid in Preterm Labor

Abstract

Abstract: Background: Preterm birth is a common problem in obstetrical field. Although in recent years morbidity and mortality of premature infants has decreased, less improvement in prediction and prevention of preterm delivery has been attained. Cytokines such as interlukin-6 and interleukin -8 in women with preterm labor are used to preterm delivery. The purpose of this study was to measure maternal serum interlukin-6 in mothers with preterm uterine contraction and compare it with cervicovaginal interlukin-6 in the same women. Methods: In this cross-sectional study, we measured interlukin-6 in serum and cervicovaginal fluid of 86 women with preterm uterine contractions. All participants had an intact. Interlukin-6 was measured by using the ELISA method. All participants were followed up until delivery. The serum and cervicovaginal interlukin-6 had not normal distribution. Statistical analysis was done using U-Man Whitney and Spearman tests. Result: In our study, the median (Quartile25, Quartile75) of interlukin-6 in cervicovaginal fluid was higher than maternal serum interlukin-6. There was a statically significant difference in the median of serum and cervicovaginal interlukin-6 in preterm labor (p<0.0001). there was not a significant correlation between serum and cervicovaginal interlukin-6(r=0.048,P=0.548). Conclusions: Our research showed that there is not any relationship between serum interlukin-6 and preterm labor.