Evaluation of the Relationship between Clinical and Laboratory Symptoms in Patients with Multiple Myeloma before Autologous Bone Marrow Transplantation with Engraftment Time

Abstract

The aim of this study was to determine the relationship between clinical and laboratory symptoms in patients with multiple myeloma under autologous bone marrow transplantation with engraftment time. Materials and Methods: The variables studied in this study were all extracted from the records of these patients and written in the data collection form. Clinical symptoms of patients include: systolic and diastolic blood pressure, heart rate, respiration rate, body temperature, number of days of fever and neutropenia. it placed. Laboratory findings of patients include: ESR, CRP, LDH, Ferritin, Serum Albumin, platelet count, hemoglobin, hematocrit, neutrophil count, lymphocyte count, UC LUC and MPXI. The above variables were recorded and compared before and after surgery. Results: Based on the results of the present study, the mean age of the patients was 44.96±9.78 years. Comparison of laboratory variables of patients in pre-transplant time, transplant time and after engraftment showed that in comparison of pre-transplant time with engraftment time, there was a statistically significant difference in ESR (increase), ferritin (increase), hemoglobin (decrease), Platelets (decrease), LUC (increase) and MPXI (decrease) were observed. Comparing the graft time with the engraftment time, statistically significant differences were observed in ESR (increase), albumin (decrease), hemoglobin (decrease), platelets (decrease), LVC (increase) and MPXI (increase). Comparing the number of fever and neutropenia days with Engraftment day did not show a statistically significant correlation (p=0.879; rP=-0.022) and the correlation between the number of platelet units and packed cell received by patients with Engraftment day was observed. Failed (p=0.090; rp=0.243 and p=0.860; rP=0.026, respectively).