The comparison of electroencephalography coherence in methamphetamine users and healthy people

Abstract

Methamphetamine overuse has severe cognitive and neuropsychological effects. Defining the effect of this drug on brain activity could be helpful in treatment and prevention of methamphetamine abuse. Coherence is seen in quantitative electroencephalography (EEG) in patients with drug abuse. In this study we aim to compare EEG coherence in methamphetamine users and healthy people. Methods: In this descriptive analytical study, 18 patients in methamphetamine abstinence and 18 healthy subjects with no history of psychological disease were evaluated. EEG was recorded in eyes open and eyes closed for each group and then analysis related to coherence between different twin electrodes was performed. The evaluation was done on occipital, temporal and parietal lobes. Results: Coherence difference in Frontal, temporal and occipital lobes were not significant. Coherence in parietal lobes were significantly different between groups (p=0.03) among them only the decrease in c3-cz electrode coherence in both Delta and Theta bands in Methamphetamine users were significant. Methamphetamine group compared to control group had significantly lower absolute power in Fz, Cz and Pz electrodes according to four band frequency in Delta and Theta (p=0.01).