Effect of injection of follicular fluid into uterine cavity implantation rate in IVF cycles

Abstract

The present study sought to examine the effectiveness of intrauterine injection of follicular fluid in in vitro fertilization (IVF).Methods & MaterialsIn a randomized, controlled clinical trial, a total of 110 female candidates for IVF were categorized into two case (n=55) and control (n=55) groups. Following an identical protocol of GnRH antagonist stimulating ovulation in both groups, in the case group a total of 2mL of follicular fluid was injected intrauterinely after the accomplishment of follicular puncture. Embryo transfer was carried out 2-3 days after the ovarian puncture. The rates of implantation, as well as chemical and clinical pregnancy were compared between the two groups. ResultsPatients in both groups were comparable in terms of age, duration of infertility, underlying cause of infertility, and variables in relation to IVF prior to implantation. Chemical pregnancy was detected in 19 cases (34.5%) vs. 23 controls (41.8%) with no significant difference between the two groups (p=0.43). Similarly, the two groups did not differ significantly in terms of clinical pregnancy rate (30.9% vs. 38.2%, respectively; p=0.42). The mean implantation rate was 11.52±2.57 % (range, 0-66.7) in cases and 18.79±3.72 % (range, 0-100) in controls. No significant difference was observed between the two groups in this regard (p=0.36).