Immunocytochemistry )TTF1-CK7-HBME1-Calretinin-CEA( in Differentiating Primary Malignant Plural Effusion and Metastatic Lung Cancers

Abstract

The aim of this study was to examine the combination of immunohistochemistry (TTF1-CK7-HBME1-Calretinin-CEA) in differential diagnosis of primary malignant pleural effusion from metastatic pulmonary cancers. Methods: Twenty samples from the pathology department archive of Tabriz Imam Reza Hospital, whose pathology reports were mesothelioma tumors and metastatic adenocarcinomas of the lung, and their tissue samples in a paraffin block for performing immunohistochemistry in terms of tissue quality and quantity were suitable, were included the study and were evaluated and compared by TTF1-CK7-HBME1-Calretinin-CEA markers. Results: In patients with adenocarcinoma CK7 in 100% (13 patients), TTF1 in 61.5% (8 patients) and CEA in 53.8% (7 patients) was positive and HBME1 and calretinin were negative in all patients. In patients with mesothelioma, HBME1 and calretinin were positive in 100% (7 patients) and TTF1, CEA and CK7 were negative in 100% (7 patients).