Evaluation of salivary and serum Homocysteine levels in Oral Squamus Cell Carcinoma patients and Healthy subjects

Abstract

Introducton: Oral cancer is one of the most common cancers in the world, accounting for more than 90% of cancers of the oral cavity is the oral squamous cell carcinoma (OSCC). Recently, researchers have focused on identifying factors that affect the organic treatment of this cancer, one of which is Homocysteine. Purpose: The aim of this study was to compare the serum and salivary levels of Homocysteine in patients with oral squamous cell carcinoma with healthy people. Material and Methods: In this descriptive study, the target population of 21 people was selected among patients with oral squamous cell Carcinoma referred to Department of Oral and Maxillofacial Medicine, Faculty of Dentistry and Department of Otolaryngology, Imam-Reza hospital. And 21 people were selected as control group. 2cc saliva samples received from each group. Homocysteine levels of the samples were evaluated by the Human Homocysteine(HCY) ELISIA Kit. The mean difference test for independent groups and Chi-square test at 95% confidence level were used for analyzing the research data. Results: The results of this study showed that serum Homocysteine levels in oral squamous cell carcinoma (3.71±2.5 ng/mL) significantly increased compared to healthy subjects (2.01±2.11 ng/mL) is less (P-value=0.008). It was also observed that Homocysteine levels in saliva were more in squamous cell carcinoma patients (3.12±1.66 ng/mL) than in healthy subjects (2.93±1/71ng/mL). (P-value=0.782) The results of this study showed that there was not a significant and statistically significant correlation between serum and salivary levels of Homocysteine in healthy individuals and squamous cell carcinoma). Conclusions: Given that serum and salivary levels of Homocysteine in patients with oral SCCs are more than healthy subjects in this study, increased levels of Homocysteine are likely to be associated with the pathogenesis of the disease. To investigate the effect of Homocysteine levels on early detection, prevention of SCC disease requires more studies.It seems that the assessment and determination of Homocysteine be influential in early detection of oral squamous cell carcinoma (OSCC) and improve. Therefore, it is recommended that dentists and doctors consider Survey of Homocysteine levels.