Evaluation and study of antimicrobial activity of nanoliposomal meropenem against Pseudomonas aeruginosa isolates

Abstract

Pseudomonas aeruginosa is a Gram negative bacilli and opportunistic pathogen that is associated with infection in burn wounds. In around the world beta-lactam antibiotic-resistant P. aeruginosa is increasing. Therefore, for the control of P. aeruginosa infections, carbapenems such as imipenem and meropenem are used. Today, liposomes are one of the most desirable new carriers in drug delivery systems because they are biocompatible and capable of carrying hydrophilic and lipophilic drugs. Previous studies have shown that liposomal gentamycin were significant effect against gentamicin resistant of P. aeruginosa. The aim of this study was to evaluate the antimicrobial efficacy of liposomal meropenem formulation against clinical and laboratory isolates of Pseudomonas aeruginosa.