The importance of dielectric constant for drug solubility prediction in binary solvent mixtures: Electrolytes and zwitterions in water+ethanol

Abstract

Improving solubility prediction methods or making them easy to use is highly demanded in the pharmaceutical industries. It can be used in formulation design and pharmaceutically related processes such as crystallization. In this work, we have showed that dielectric constants of solvents and their mixtures might be helpful in solubility prediction of electrolytes and zwitterions with acceptable error in water+ ethanol mixtures. é 2010 American Association of Pharmaceutical Scientists.