The effect of maternal hypoxia on blood glucose before and after administration of ketamine in rabbit kits

Abstract

Commonly used anesthetics such as ketamine can differentially affect a number of physiological parameters include hyperglycemia. We aimed this study to determine the effect of maternal hypoxia on blood glucose before and after ketamine administration. Six healthy pregnant rabbits, divided into two groups. Control pregnant rabbits inspired normal air. The case rabbits were subjected to 20 minutes daily period of hypoxia for 10 days during first third of pregnancy for first subgroup and during second third for second subgroup. Blood glucose levels were measured immediately before administration of ketamine (50 mg/kg) and 30, 60, 90 and 120 min after injection. According to results there was a significant difference in glucose concentration between case and control groups before injection. Elevation of blood glucose levels occurred 30 minutes after injection only in control group but it decreased in both subgroups of case animals. Elevation of blood glucose continued in control and began in case group 60 minutes after injection of ketamine but blood glucose decreased 90 minutes after it at all of animals. Taken together, these findings verified influence of maternal hypoxia on postnatal blood glucose. According to results maternal hypoxia caused contrary effect of ketamine on blood glucose in rabbit kits.