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Solubility of Ketoconazole in Ethanol + Water Mixtures at Various Temperatures

dc.contributor.authorHashemzadeh, N
dc.contributor.authorJouyban, A
dc.date.accessioned2018-08-26T09:35:33Z
dc.date.available2018-08-26T09:35:33Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57883
dc.description.abstractKetoconazole is an important drug with low water solubility. Its low aqueous solubility could be increased using various methods such as by the addition of a pharmaceutical cosolvent. The solubility of ketoconazole in ethanol + water mixtures at 293.2, 298.2, 303.2, and 308.2 K were determined, and the results showed that the addition of ethanol increased the solubility and the maximum value was obtained at 80% of ethanol. The generated data were mathematically represented using the Jouyban-Acree model within an acceptable accuracy. © 2015, Taylor & Francis Group, LLC.
dc.language.isoEnglish
dc.relation.ispartofChemical Engineering Communications
dc.subjectEthanol
dc.subjectMixtures
dc.subjectAqueous solubility
dc.subjectCosolvents
dc.subjectKetoconazole
dc.subjectLow water
dc.subjectSolubility prediction
dc.subjectWater mixture
dc.subjectSolubility
dc.titleSolubility of Ketoconazole in Ethanol + Water Mixtures at Various Temperatures
dc.typeArticle
dc.citation.volume202
dc.citation.issue9
dc.citation.spage1211
dc.citation.epage1215
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1080/00986445.2014.912636


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