Solubility of Ketoconazole in Ethanol + Water Mixtures at Various Temperatures

Abstract

Ketoconazole is an important drug with low water solubility. Its low aqueous solubility could be increased using various methods such as by the addition of a pharmaceutical cosolvent. The solubility of ketoconazole in ethanol + water mixtures at 293.2, 298.2, 303.2, and 308.2 K were determined, and the results showed that the addition of ethanol increased the solubility and the maximum value was obtained at 80% of ethanol. The generated data were mathematically represented using the Jouyban-Acree model within an acceptable accuracy. © 2015, Taylor & Francis Group, LLC.