Solubility of 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5- diiodophenyl ketone hydrochloride (amiodarone HCl) in ethanol + water and N-methyl-2-pyrrolidone + water mixtures at various temperatures

Abstract

The solubilities of amiodarone HCl (AMDH) in binary mixtures of ethanol + water and N-methyl pyrrolidone (NMP) + water at (293.2, 298.2, 303.2, 308.2, and 313.2) K are reported. In the ethanol + water system the maximum solubility of AMDH was observed at 313.2 K and an ethanol mass fraction of 0.76. The combination of the Jouyban-Acree model and van't Hoff equation was used to predict the solubility of AMDH in the mixed solvents at different temperatures. A mean relative deviation of 12.2 % was obtained for the correlated data. The standard enthalpy, entropy,and Gibbs energy changes of solutions for AMDH in ethanol + water and NMP + water mixtures were calculated from the measured solubility data using the modified version of the van't Hoff equation. © 2012 American Chemical Society.