Immunophenotyping of acute leukemia in northwestern Iran

Abstract

The significance of immunophenotyping is growing day by day. It provides basic information in regard to classification and prognosis of acute leukemia which helps the management of patients. This study was conducted to Identify CD markers in leukemic patients admitted to Tabriz, in northwestern Iran. Immunophenotyping of 60 patients with acute leukemia was determined. Patients with acute myelogenous leukemia (AML) were 42% of M2 type, 23.6% M3, 15.7% M4, 13% M1 and 5.7% M5. CD13 and CD33 were the most prevalent myeloid markers. T-lymphoid markers consisted mainly of CD7 and its occurrence was mostly in M2 and M4, and least in M3 subtypes. The most common lymphoid markers in patients with T-cell acute lymphoblastic leukemia (ALL) were CD2, CD3, CD7 and in those with B-cell ALL were CD10, CD19 and HLA-DR. The most prevalent myeloid markers in T-ALL were CD14, CD33 and CD13.