High-sensitivity C-reactive protein and tumor necrosis factor alpha in pseudoexfoliation syndrome

Abstract

Objectives: Te purpose of the present study was to determine the alterations in high-sensitivity C-reactive protein and Tumor Necrosis factor alpha levels in the blood serum of pseudoexfoliation syndrome cases (a disease with similar risk factors as systemic endothelial dysfunction diseases) and to compare the results with healthy individuals. Methods: High-sensitivity C-reactive protein and Tumor Necrosis factor alpha levels were determined in 30 cases with pseudoexfoliation syndrome and in 30 control patients of the same age and sex, by enzyme-linked immunosorbent assay. Results: Te levels of high- sensitivity C-reactive protein and Tumor Necrosis factor alpha in the blood serum of patients with pseudoexfoliation syndrome (3.95آ±0.88 mg/l, 3.32آ±0.99 pg/ ml, respectively) were signifcantly higher than in the control group (2.51آ±0.79mg/l, 0.43آ±0.15 pg/ml, respectively) p=0.001, p=0.002. Conclusion: Te results suggest that increased levels of high-sensitivity C-reactive protein and Tumor Necrosis factor alpha, as markers of infammation and peripheral endothelial dysfunction in pseudoexfoliation syndrome, may be risk factors for systemic and ocular manifestations of pseudoexfoliation syndrome. آ© OMSB, 2013.