Fibrotic and apoptotic markers alteration in ovariectomised rats: addition of swimming training preserves lung architecture
چکیده
Context: The important role of exercise in pulmonary function during menopause is not well known. Oestrogen deficiency in ageing female mice is accompanied by increase in apoptotic markers such as caspase3 in the lung. Objective: The present study was designed to investigate whether swimming training will ameliorate fibrosis and apoptosis resolution in the ovariectomy-induced lung injury rats. Material and method: Thirty female rats were assigned to three groups (n?=?10 in each group): sham; rats underwent bilateral laparotomy without ovariectomy, OVX; rats underwent bilateral ovariectomy, OVX.Exe; ovariectomised rats that underwent swimming training for eight weeks. At the end of eight weeks, the lungs were harvested and protein expressions in whole lung tissues were analysed by western blotting technique. Result: Analysis of proteins expression in the lung showed significant differences between exercise and ovariectomised group (p?<?.05). Conclusion: The present study indicates strong potential of exercise in experimental oestrogen deficiency-induced lung damage. é 2017 Informa UK Limited, trading as Taylor & Francis Group