Comparison of oral pantoprazole and famotidine on gastric volume and ph in elective surgeries

Abstract

Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH and volume of aspirated gastric juice. Because of the loss of consciousness while anesthesia, the protective reflexes disappear and expose the person in the risk of aspiration. Pharmacological attempts have been made to eliminate the risk of pulmonary aspiration. The aim of this study was to compare oral pantoprazole and famotidine on gastric volume and pH in elective surgeries. Methods: In a double-blind randomized clinical trial, 120 candidates of elective surgery were randomized into 3 groups (control or C, pantoprazole or P and famotidine or F groups). The patients in group C 'P and F were given placebo 'pantoprazole 40mg and famotidine 40mg orally at 11 pm a night before surgery respectively. After induction of anesthesia, gastric contents were aspirated and analyzed for the pH and volume. Results: PH values were 2.87آ±0.92 in group C, 4.53آ±1.29 in group P and 3.79آ±1.97 in group F. There was statistical difference between groups C, P and F (p<0.05). The results showed a considerable decrease in the gastric volume in groups P and F comparing to group C. (p<0.05). Conclusion: We concluded that oral pantoprazole is effective in reducing gastric pH comparing to famotidine and placebo'and famotidine is effective in reducing gastric volume comparing to pantoprazole.