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dc.contributor.authorHajipour, B
dc.contributor.authorSomi, MH
dc.contributor.authorDibazar, F
dc.contributor.authorAsl, NA
dc.contributor.authorVatankhah, AM
dc.date.accessioned2018-08-26T08:34:48Z
dc.date.available2018-08-26T08:34:48Z
dc.date.issued2010
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52585
dc.description.abstractIn this research we studied simvastatin effect on liver and lung tissue anti-oxidant enzymes, 24 h after hepatic I/R. Male Wistar rats were randomly assigned into three groups of fifteen animals in each group. Group 1, the sham group, underwent laparotomy but did not experience I/R; group 2, the I/R group, underwent ischaemia for 30 min and were reperfused for 24 h; Group 3 underwent ischaemia and reperfusion like group 2 but also received 10 mg kg-1 simvastatin dissolved in water by oral gavage for three days before the operation. In animals subjected to hepatic I/R port triad clamped for 30 min following by 24 h reperfusion. Data showed that GPx and SOD levels in liver and lung tissue in I/R+simvastatin group were higher than I/R group significantly (p<0.05). MDA level in I/R group was significantly higher than I/R+simvastatin group in liver and lung tissue significantly (p<0.05). As simvastatin is a safe drug and result of our previous research and also this research show the efficacy of simvastatin pretreatment in decreasing liver and lung oxidative stress after hepatic I/R, so it may be useful in attenuating hepatic I/R injury and it may be effective for performing safer hepatic surgeries.
dc.language.isoEnglish
dc.relation.ispartofJournal of Medical Sciences
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectsimvastatin
dc.subjectsuperoxide dismutase
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjectlipid peroxidation
dc.subjectliver injury
dc.subjectliver ischemia
dc.subjectliver level
dc.subjectlung injury
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectreperfusion injury
dc.titleAnti-oxidative effect of simvastatin in liver and lung tissue after hepatic ischemia/reperfusion in rat
dc.typeArticle
dc.citation.volume10
dc.citation.issue3
dc.citation.spage66
dc.citation.epage70
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.3923/jms.2010.66.70


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