Chameleonic effect and some models for predicting drug solubility in solvent mixtures

Abstract

A new model derived from an excess free energy approach which expresses drug solubility in solvent mixtures showing multiple solubility peaks, the chameleonic effect, with respect to the concentrations of solvents in a mixture is proposed. Accuracy and predictability of the model are compared with those of a previous model which expresses drug solubility based on Hildebrand, acidic and basic solubility parameters. The results indicate that the new model is more accurate than the previous model and average percent mean errors are 5.32 and 13.66, respectively.