Evaluation of hemostatic factors in children with nephrotic syndrome

Abstract

Objective: Thromboembolism (TE) is one of the serious complications of nephrotic syndrome (NS). The aim of this study was to evaluate the haemostatic factors in children with nephrotic syndrome. Methodology: Plasma Level of protein C, Protein S, fibirinogen and antithrombin III (AT III) were evaluated in thirty nephrotic children at relapse and remission period and the results were compared with those of 30 healthy children. Results: The mean age of patients was 5.38 +/- 3.07 years. Plasma level of protein S and AT III during relapse were significantly lower than their level in remission period and in control group. The mean fibrinogen level during relapse was significantly higher than its Level in remission period and in control group. There was no significant difference in protein C Levels at relapse with remission period and with control group. Serum albumin Levels during relapse were positively correlated with AT III levels. There was no correlation between urinary protein excretion and the haemostatic factors. Conclusions: Despite reduced Levels of AT III and protein S and increased levels of fibrinogen, none of our patients revealed thromboembolism. It seems that coexistence of several factors is necessary to induce TE.