Solubility of Lamotrigine, Diazepam, Clonazepam, and Phenobarbital in Propylene Glycol plus Water Mixtures at 298.15 K

Abstract

Experimental solubilities of four antiepileptic drugs, that is, lamotrigine, diazepam, clonazepam, and phenobarbital in propylene glycol + water mixtures at 298.15 K were reported. The solubility of drugs was increased with the addition of propylene glycol, and the maximum values are observed in neat propylene glycol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean deviations (OMDs) of the models were 6.0 % and 14.3 %, respectively. Solubilities were also predicted by a previously established log-linear model of Yalkowsky with an OMD of 37.7 %. More accurate predictions, were provided using the Jouyban-Acree model in comparison with the log-linear model of Yalkowsky.