Effect of E. laciniata (L) Ointment on Mild and Moderate Carpal Tunnel Syndrome: A Double-blind, Randomized Clinical Trial

Abstract

This paper concerns the effects of methanol extract of Eremostachys laciniata on mild and moderate Carpal Tunnel Syndrome (CTS). Forty patients, including sixty hands affected by CTS, were randomly categorized in two different groups. Group A and Group B were treated with E. laciniata extract and placebo as the ointment, respectively. Tests, including the palmar prehension (pound), grip power (kg), visual analog scale (VAS) and electrodiagnostic study, were performed on all patients before and after the trial. During the trial, all patients receive Sodium Diclofenac (25 mg twice a day) orally. In addition, they utilized a night wrist splint. After four weeks of treatment, the state of mean palmer prehension in both groups improved yet, the statistics show that group A prevailed by (p = 0.01). Grip power increased in both groups as well, but this increase was not significant within-groups (p = 0.18 and p = 0.54 in group A and B, respectively) or between-groups (p = 0.053). Although the VSA decreased in both groups, group A prevailed again by (p < 0.001). After four weeks, no significant electrodiagnostic change was detected between the two groups. According to this study, the methanol extract of E. laciniata can be effective in treatment of mild and moderate CTS in combination with the wrist night splint, especially in alleviating the severity of the syndrome and increasing the palmer prehension power. Copyright (C) 2010 John Wiley & Sons, Ltd.