Solubility Prediction of Drugs in Mixed Solvents Using Partial Solubility Parameters

Abstract

Solubility of drugs in binary and ternary solvent mixtures composed of water and pharmaceutical cosolvents at different temperatures were predicted using the Jouyban-Acree model and a combination of partial solubility parameters as interaction descriptors in the solution. The generally trained version of the model produced the overall mean percentage deviation values for the back-calculated solubility of drugs in binary solvents of 34.3% and the predicted solubilities in ternary solvent mixtures of 38.0%. In addition, the applicability of the trained model for predicting the solvent composition providing the maximum solubility of a drug was investigated. The results of collected solubility data of drugs in various mixed solvents and the newly measured solubility data of five drugs in ethanol + propylene glycol + water mixtures at 25 degrees C showed that the model provided acceptable predictions and could be used in the pharmaceutical industry. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:4368-4382, 2011