Solubility of drugs in ethyl acetate-ethanol mixtures at various temperatures

Abstract

A generally trained version of the Jouyban-Acree model is presented employing 51 solubility data sets of 19 drugs in ethyl acetate + ethanol mixtures at various temperatures. Using this model, the solubilities of a drug in ethyl acetate and ethanol are required to predict the solubility in ethyl acetate + ethanol mixtures. The overall percentage deviation (%D)for the correlated data was 10.9%.