| dc.contributor.author | Rodriguez, GA | |
| dc.contributor.author | Delgado, DR | |
| dc.contributor.author | Martinez, F | |
| dc.contributor.author | Jouyban, A | |
| dc.contributor.author | Acree, WE | |
| dc.date.accessioned | 2018-08-26T08:05:15Z | |
| dc.date.available | 2018-08-26T08:05:15Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/49775 | |
| dc.description.abstract | By using the van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and of mixing of naproxen (NAP) in some ethyl acetate + ethanol mixtures were evaluated from solubility data determined at several temperatures. By means of enthalpy-entropy compensation analysis, a non linear Delta H-soIn degrees vs. Delta(soIn)G degrees compensation plot with negative and positive slopes was obtained if all the composition intervals are considered. Finally, the Jouyban-Acree model has been applied to correlate the drug solubilities as well as the respective thermodynamic quantities of solution in these solvent mixtures. (C) 2012 Elsevier B.V. All rights reserved. | |
| dc.language.iso | English | |
| dc.relation.ispartof | FLUID PHASE EQUILIBRIA | |
| dc.subject | Naproxen | |
| dc.subject | Solubility | |
| dc.subject | Ethyl acetate plus ethanol mixtures | |
| dc.subject | Solution thermodynamics | |
| dc.subject | Jouyban-Acree model | |
| dc.title | Solubility of naproxen in ethyl acetate plus ethanol mixtures at several temperatures and correlation with the Jouyban-Acree model | |
| dc.type | Article | |
| dc.citation.volume | 320 | |
| dc.citation.spage | 49 | |
| dc.citation.epage | 55 | |
| dc.citation.index | Web of science | |
| dc.identifier.DOI | https://doi.org/10.1016/j.fluid.2012.02.009 | |
