Solubility of naproxen in ethyl acetate plus ethanol mixtures at several temperatures and correlation with the Jouyban-Acree model
چکیده
By using the van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and of mixing of naproxen (NAP) in some ethyl acetate + ethanol mixtures were evaluated from solubility data determined at several temperatures. By means of enthalpy-entropy compensation analysis, a non linear Delta H-soIn degrees vs. Delta(soIn)G degrees compensation plot with negative and positive slopes was obtained if all the composition intervals are considered. Finally, the Jouyban-Acree model has been applied to correlate the drug solubilities as well as the respective thermodynamic quantities of solution in these solvent mixtures. (C) 2012 Elsevier B.V. All rights reserved.