Solubility of lamotrigine in binary and ternary mixtures of N-methyl pyrrolidone and water with polyethylene glycols 200, 400, and 600 at 298.2 K

Abstract

The solubility of lamotrigine in binary and ternary mixtures of N-methyl pyrrolidone and water with polyethylene glycols 200, 400, and 600 at 25 degrees C is determined and mathematically represented using two cosolvency models, i.e. the log-linear model of Yalkowsky (method I), the Jouyban-Acree model (method II), and a combined version of the Jouyban-Acree model with Hansen partial solubility parameters (method III). The density of the solute free solvent mixtures is measured and employed to train the Jouyban-Acree model and subsequently the density of the saturated solutions is predicted. For methods I and II, the overall mean relative deviations (OMRDs) for fitting the solubility data of lamotrigine in binary mixtures are 39.1% and 5.1%, respectively. Further, the OMRDs for fitting the solubilities in ternary solvent mixtures for lamotrigine are 42.9% and 22.1% for methods land II, respectively. In method III, the OMRD value for fitting all 122 data points by means of the combined version of the Jouyban-Acree model with Hansen solubility parameters is 12.7%. The trained version of the Jouyban-Acree model was produced by using the density of the solute free solutions, and the prediction of OMRD for the density of saturated solutions is 1.6%. (C) 2012 Elsevier B.V. All rights reserved.