Solubility of Lamotrigine in Propylene Glycol plus Ethanol and Their Ternary Aqueous Mixtures

Abstract

The solubility of lamotrigin in binary mixtures of propylene glycol (PG) + ethanol, and ternary mixtures of PG + ethanol + water at 298.2 K was reported. The measured solubility data was mathematically represented using the Jouyban-Acree model. The accuracies of the calculated solubilities were evaluated by computing mean percentage deviation MPDs (+/- SD); the obtained MPDs were 2.9 +/- 3.4 % for binary and 10.4 +/- 6.8 % for ternary solvent mixtures.