Solubility of Ketoconazole in Polyethylene Glycol 200+Water Mixtures at 298.2-318.2 K

Abstract

The solubility of ketoconazole in binary mixtures of polyethylene glycol 200 (PEG 200) + water is reported at temperatures ranging from 298.2 to 318.2 K. The Jouyban-Acree model and its combined version including the van't Hoff equation were used for correlating the reported data; the obtained mean relative deviations are 9.5 and 9.9 %, respectively. Also, two previously trained versions of the Jouyban-Acree model were used for predicting the reported data points in which the prediction errors were 34.6 and 31.0 %.