Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Abstract

Experimental solubility of lamotrigine in binary mixtures of methanol + acetone, ethanol + acetone, 1-propanol + acetone, ethyl acetate + acetone, ethyl acetate + methanol, ethyl acetate + ethanol, ethyl acetate + 1-propanol at 298.2 K are reported. The measured data were fitted to the Jouyban-Acree model and the overall mean percentage deviation (MPD) of back-calculated solubilities was 4.0 %. Also, densities of the saturated solutions were measured and fitted to the Jouyban-Acree model. The overall MPD value for this analysis was 6.0 %.